I'm right-handed and therefore prefer my computer mouse to be on the right. But during my AF civil service days I worked in one office cubicle that was arranged so that I had to mouse with my left hand. It was different, but I actually caught on a lot quicker than I imagined I would.
The point of that is that I didn't realize that setup was one of 3 Easy Ways to Improve Your Brain Power.
That is if you're even interested in doing so. One should never presume, eh? :-)
Plus, I don't know if it made me any smarter... although I did get a promotion out of that job... so maybe it was the mouse thing after all!